In the 21st century, the existence of humanoid "Beastmen"—who possess the ability to shift shape between human and animal forms—is revealed to the world after centuries of hiding. To escape human persecution, a sanctuary called Anima City is established. Michiru Kagemori, an ordinary human high school student, suddenly transforms into a tanuki (raccoon dog) Beastman without warning. Terrified and hunted, she flees to Anima City to seek answers and find a potential cure. There, she encounters Shirou Ogami, a stoic and powerful wolf Beastman with an intense hatred for humans. As Michiru adjusts to her strange new physical capabilities and works alongside Shirou to protect the city, the duo stumbles into a massive corporate and evolutionary conspiracy that threatens the very survival of all Beastmen.